A legal storm is brewing across the U.S. as more women come forward alleging that Pfizer’s birth control shot, Depo-Provera, caused them serious harm. The focus? A growing link between long-term use of the contraceptive and meningioma brain tumors—a potentially life-altering diagnosis.
With lawsuits piling up and the court consolidating them into a Multi-District Litigation (MDL), this case is quickly gaining national traction.
If you or a loved one have used Depo-Provera and been diagnosed with a brain tumor, here’s the full picture—from lawsuit details to who qualifies, how to file, expected payouts, and what comes next.
Background
Depo-Provera, a hormone-based birth control injection, has been widely used since the 1990s. But recent studies are revealing a disturbing side effect: a significantly increased risk of intracranial meningiomas—non-cancerous but dangerous brain tumors that can cause serious symptoms or require invasive surgeries.
One key study showed that women who received two or more Depo shots faced a notably higher risk of developing these tumors. For many, the connection only became clear after experiencing seizures, vision loss, or undergoing major surgeries. The lawsuits claim that Pfizer failed to provide adequate warnings, leaving thousands unaware of the risk.
Eligibility
Wondering if you might qualify to file a claim? Here’s a breakdown of the main criteria:
- You received at least two Depo-Provera injections.
- You were later diagnosed with a meningioma brain tumor.
- You have medical documentation proving both the injections and the diagnosis.
- Your diagnosis happened after using Depo-Provera.
- You are filing within your state’s legal time limit.
If you check all the boxes, you’re likely eligible to join the ongoing MDL litigation, even if no final settlement has been reached yet.
Filing
Thanks to a recent court decision, the process is more streamlined than ever. Here’s how to file a Depo-Provera claim:
- Contact a law firm that handles pharmaceutical injury cases. Most offer free consultations.
- Collect documentation—your prescription records, doctor notes, scans, and a timeline of your symptoms.
- File directly into MDL 3140, regardless of where you live.
- Submit the required questionnaire and medical proof of Depo use and tumor diagnosis.
- Once accepted, your claim enters the litigation phase—discovery, depositions, and possibly a trial or settlement.
This is a nationwide litigation effort, so women from any U.S. state can participate as long as they meet the criteria.
Payouts
No global settlement has been announced—yet. But based on similar pharmaceutical cases, legal analysts expect potential settlements to fall within these ranges:
| Severity of Case | Estimated Settlement Range |
|---|---|
| Mild (non-surgical, recovered) | $50,000 – $100,000 |
| Moderate (surgery but no lasting damage) | $100,000 – $250,000 |
| Severe (lifelong impairment or disability) | $250,000 – $500,000+ |
Final settlement amounts will depend on your medical bills, how much work you missed, pain and suffering, and long-term health impact. Early bellwether trials—expected in early 2026—will shape how much Pfizer might offer to settle future claims.
Risks
While brain tumors are the headline issue, new cases are pointing to other severe complications too. A 21-year-old woman developed Phlegmasia Cerulea Dolens, a rare and life-threatening blood clotting disorder, after taking Depo-Provera. Although blood clots are a listed risk, this extreme case has raised fresh concerns about how thoroughly Pfizer warned users.
Plaintiffs are now arguing that the company downplayed several serious risks, strengthening the legal case for liability.
Timeline
Here’s what to expect as the legal calendar moves forward:
| Key Date | Event Description |
|---|---|
| May 11, 2025 | Pfizer to complete causation-related document production |
| July 25, 2025 | Discovery on legal defenses like preemption ends |
| August 2025 | Summary judgment motions begin |
| February 2026 | Expert witness discovery phase wraps up |
| 2026 (TBD) | Bellwether trials start—likely triggering settlement talks |
As this unfolds, the pressure on Pfizer is expected to grow—making it critical for affected individuals to act fast and join the case if eligible.
The Depo-Provera brain tumor lawsuits are becoming one of the biggest pharmaceutical battles of the decade. If the court sides with the plaintiffs and bellwether trials go well, this could lead to a massive settlement. For thousands of women who’ve suffered in silence, this lawsuit may finally bring justice—and financial relief.
If you’ve used Depo-Provera and developed a meningioma or other severe side effects, don’t wait. The legal window won’t stay open forever.
FAQs
Who qualifies for the Depo lawsuit?
Women with 2+ injections and a meningioma diagnosis.
Do I need a lawyer to file a claim?
Yes, an attorney helps gather records and file into MDL.
What is the potential payout?
Anywhere from $50,000 to $500,000+ based on severity.
Can I file from any state?
Yes, claims can be filed directly into the Florida MDL.
When will trials begin?
Bellwether trials are expected in early 2026.
